CREGULOME: AN R PACKAGE FOR ACCESSING MICRORNA AND TRANSCRIPTION FACTOR-GENE EXPRESSION CORRELATIONS IN CANCER

cRegulome: an R package for accessing microRNA and transcription factor-gene expression correlations in cancer

Background Transcription factors and microRNAs play a critical role in regulating the gene expression in normal physiology and pathological conditions.Many bioinformatics tools were built to predict and identify transcription factor and microRNA targets and their role in the development of diseases including cancers.The availability of public acces

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Myocardial Ablation of G Protein-Coupled Receptor Kinase 2 (GRK2) Decreases Ischemia/Reperfusion Injury through an Anti-Intrinsic Apoptotic Pathway.

Studies from our lab have shown that decreasing myocardial G protein-coupled receptor kinase 2 (GRK2) activity and expression can prevent heart failure progression after myocardial infarction.Since GRK2 appears to also act as a pro-death kinase in myocytes, we investigated the effect GF MUESLI of cardiomyocyte-specific GRK2 ablation on the acute re

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